The San Francisco 49ers are a popular team from a betting perspective. It's surprising considering they are coming off a six-win season. However, their easy schedule favors them, and their injury luck should improve in 2025. Perhaps all of that will lead to them having a great enough season that leads them to a Super Bowl appearance. DraftKings sportsbook has the 49ers as one of the betting favorites to win the Super Bowl with the seventh-best odds (+2000) in the NFL.