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Joselynn R. Calderon on Muck Rack

Joselynn R. Calderon

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Characterizing non-hallucinogenic psychedelics beyond the head twitch response: phenotypic fingerprinting of lisuride and LSD

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By Jillian King, Devin P. Effinger, Janae R. Wallingford, Scott Thompson, Cameron Basquez-Pfeifer, Joselynn R. Calderon, Caden K. O’Connell
| Nature Verified
Abstract The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT2AR activation. Here, we examine how the polypharmacological agonists lisuride and lysergic acid diethylamide (LSD) influence behavioral and physiological outcomes in mice to test whether the HTR reliably reflects overall psychoactivity.
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