Josephine Barnes
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Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics - Nature
Correction to: Nature https://doi.org/10.1038/s41586-024-07575-x Published online 19 June 2024 In the version of the article initially published, the Acknowledgements was missing the following text, which has now been added to the HTML and PDF versions of the article: “The authors gratefully acknowledge support from the UK Vaccine Taskforce of the Department of Business, Energy and Industrial Strategy of Her Majesty’s Government (BEIS).
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics - Nature
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Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in seronegative individuals challenged with pre-Alpha SARS-CoV-2.
By Kaylee B. Worlock, Lisa M Dratva, Masahiro Yoshida, Helen R. Wagstaffe, Laura Richardson, Josephine Barnes, Lorenz Kretschmer, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja A. Mehta, Jacqueline M. Boccacino, Waradon Sungnak, Rasa Elmentaite, Ni Huang, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Leo Swadling, Claire Smith, Vitor H. Teixeira, Vítor Teixeira, Sam M. Janes, Rachel Chambers Verified, Muzlifah Haniffa, Robert S Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B Meyer, Christopher J Chiu, Marko Nikolic
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Nature
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Rates of cortical thinning in Alzheimer’s disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70
Discussion In CN adults ~70 years old, higher baseline WMHV—a marker of CSVD—related to significantly faster subsequent rates of cortical thinning in AD signature regions, whereas baseline Aβ status did not.
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