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ABSTRACT Clopidogrel is a widely prescribed antiplatelet prodrug, with activation affected by CYP2C19 loss- and gain-of-function variants. Whilst global CYP2C19 variant prevalence is well described, this scoping review characterises CYP2C19 diplotype and metaboliser phenotype frequencies in clopidogrel-indicated populations. A literature search of Scopus, PubMed, Ovid MEDLINE, and Ovid Embase was conducted from inception to 6 July 2026.
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