Joseph Longo
Verified
As seen in:
BuzzFeed,
MSN,
Yahoo Entertainment,
Yahoo Life,
Forbes,
Nature,
The Wall Street Journal,
The Washington Post,
TIME,
Yahoo Canada,
Yahoo News Malaysia
and
Senior editor, @buzzfeed
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Joseph Longo
Sulfur partitioning from cysteine controls T cell proliferation and effector function
keywords immunometabolism CD8+ T cells cysteine anti-tumor immunity glutathione mitochondria Fe-S clusters iron uptake T cell exhaustion lipid peroxidation Introduction CD8+ T cell activation in response to antigen and costimulation is accompanied by cell growth, proliferation, and acquisition of effector functions, including cytolytic capacity and expression of interferon (IFN)γ and tumor necrosis factor (TNF).
Forbes JAPAN 公式サイト（フォーブス ジャパン）
Velosioの共同創業者であるジョー・ロンゴ氏は、Velosioにおいて、収益成長と株主価値の創出に30年以上の実績を持つ。 現代の組織にとって、詳細な年間計画は運営成功のために不可欠である。Velosioでは、年間計画への取り組みが、他のクラウドアプリケーションサービスパートナーとの差別化につながっていると実感しており、それは年々の成長に表れている。この規律により、経済の低迷期を乗り切り、好況期には成長の機会を活かすことができた。私が務める複数の取締役会でも、詳細な年間計画に従う組織が、同業他社を一貫して上回るパフォーマンスを示していることを目の当たりにしてきた。 前回の記事では、効果的な年間計画プロセスを通じて運営成功を推進するという考え方を紹介した。読者には、最初のステップとして現在の運営状況を評価し、次のステップとして運営目標を設定することを勧めた。...
How To Develop A Detailed Annual Plan For Operational Success
Joe Longo, Cofounder of Velosio, has over 30 years of proven success delivering revenue growth and shareholder value. For organizations today, a detailed annual plan is critical for operational success. At Velosio, we’ve found that our commitment to annual planning has set us apart from other cloud application services partners, as evidenced by our growth year after year. This discipline has helped us navigate economic downturns and capitalize on upturns in economic growth.
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses - Nature Metabolism
Abstract Reducing calorie intake through dietary restriction (DR) slows tumour growth in mammals, yet the underlying mechanisms are poorly defined. Here, we show that DR enhances anti-tumour immunity by optimizing CD8+ T cell function within the tumour microenvironment (TME).
Nutrient allocation fuels T cell-mediated immunity
|
Keywords adaptive immunity effector function glucose immunometabolism nutrient allocation T cells Introduction T cells are the body’s specialized defenders, eliminating pathogenic and malignant threats while forging long-lasting immune memory. Their transformation from quiescent, naive T (Tn) cells to active, effector T (Teff) cells is a carefully orchestrated process.
By Joseph Longo Verified, McLane J. Watson, Kelsey Williams, Ryan D. Sheldon, Russell Jones, Russell Jones
|
Cell Metabolism
Verified
The "I Love LA" Cast Tries To Guess If Timothée Chalamet Showers Every Day
One thing about the I Love LA cast? They're competitive as hell! They're also a bunch of "It Girls " and "It Guys." So when you get them together to play a game of celebrity "Who's Who" featuring themselves, their famous collaborators, and A-list friends...ya, it's going to be a rowdy time.
The "All's Fair" Cast Completed The Puppy Interview, And It Was Incredibly Chaotic In The Best Possible Way
If there's one thing fair in the world, it's All's Fair dropping today. Hulu/Disney / Courtesy Everett Collection Ryan Murphy's glossy and soapy Hulu series about high-powered female lawyers stars Kim Kardashian, Sarah Paulson, Glenn Close, Niecy Nash, Teyana Taylor, and Naomi Watts delivering deadly one-liners in some killer looks.
The Cast Of "Chad Powers" Stopped By To Play A Game Of Who's Who, And We Learned So, So, So, So, So, So, So, So, So, So, So Much
BuzzFeed and Yahoo may earn commission from links in this article. Pricing and availability are subject to change. If you're not watching Chad Powers, what are you doing? Disney/Daniel Delgado Jr. Inspired by Eli Manning's 2022 prank persona of the same name, Chad Powers follows a disgraced college quarterback (played by the one and only Glen Powell) who disguises himself to join a different team as a walk-on player.
Robert Irwin Just Revealed Which Of His "Dancing With The Stars" Competitors Is "One To Watch"
BuzzFeed and Yahoo may earn commission from links in this article. Pricing and availability are subject to change.
Here Are 48 Movies Premiering In Fall 2025 That Are 100% Worth Checking Out
Summer is nearly over, which means one thing: It's movie season. From September through the end of the year, an onslaught of films is hitting theaters and streaming platforms. But what's worth watching? We did the legwork for you.
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells - Nature Metabolism
Abstract Cancer cells are exposed to diverse metabolites in the tumour microenvironment that are used to support the synthesis of nucleotides, amino acids and lipids needed for rapid cell proliferation. In some tumours, ketone bodies such as β-hydroxybutyrate (β-OHB), which are elevated in circulation under fasting conditions or low glycemic diets, can serve as an alternative fuel that is metabolized in the mitochondria to provide acetyl-CoA for the tricarboxylic acid (TCA) cycle.
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
|
Keywords CD8+ T cells cytotoxic function glucose glycosphingolipids immunometabolism lipidomics lipid rafts nucleotide sugar metabolism metabolomics UGCG Introduction T cells play a critical role in host defense against infections and cancer.
By Joseph Longo Verified, Lisa M. DeCamp, Brandon M. Oswald, Robert Teis, Alfredo Reyes-Oliveras, Michael S. Dahabieh, Abigail Ellis, Michael Vincent, Hannah Damico, Kristin L. Gallik, Nicole Foy Verified, Shelby E. Compton, Colt D. Capan, Kelsey Williams, Zachary Madaj, Dominic G. Roy, Connie M. Krawczyk, Brian B. Haab, Ryan D. Sheldon, Russell Jones, Corinne R. Esquibel, Hyoungjoo Lee
|
Cell Metabolism
Verified
"Parents These Days Would Have A Complete Meltdown": 15 "Everyday" Things You Wouldn't Be Caught Dead Doing Today
It's always fascinating to consider what ubiquitous aspects of modern culture weren't always so standard. So recently, we asked the BuzzFeed Community, "What's something that was so 'normal' back in the day but could NEVER happen now?" The responses were insightful and a major nostalgia trip. Here are just 15 things that really stood out: Responses have been edited for length and clarity. 1."Letting your kids outside to do and go wherever they please as long as they're home by dinner.
15 "Normal" Things From Decades Ago That Gen Z Would Never Believe Were Once Common
It's always fascinating to consider what ubiquitous aspects of modern culture weren't always so standard. So recently, we asked the BuzzFeed Community, "What's something that was so 'normal' back in the day but could NEVER happen now?" The responses were insightful and a major nostalgia trip. Here are just 15 things that really stood out: Responses have been edited for length and clarity. 1."Letting your kids outside to do and go wherever they please as long as they're home by dinner.
Setting Operational Goals: The Bridge Between Strategy And Success
Joe Longo, Cofounder of Velosio, has over 30 years of proven success delivering revenue growth and shareholder value. getty The process of operational goal-setting is a critical step when it comes to business planning. It's the step that transforms strategic plans into actionable items. I previously wrote about operational success as the backbone of any thriving organization and achieving it through effective annual planning. I then dove deeper into the first step, assessing current operations.
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion - Nature Immunology
|
Abstract CD8+ T cell exhaustion (Tex) limits immune control of cancer, but the underlying molecular drivers are unclear. In the present study, we identified the prostaglandin I2 (prostacyclin) receptor PTGIR as a cell-intrinsic regulator of T cell exhaustion. Transcriptomic profiling of terminally exhausted (Ttex) CD8+ T cells revealed increased activation of the nuclear factor erythroid 2-related factor 2 (NRF2) oxidative stress response pathway.
By Joseph Longo Verified, Kelsey Williams, Abigail E. Ellis, Chen Yao, Tuoqi Wu, Ryan D. Sheldon, Ibukunoluwa Sodiya
|
Nature
Verified
People Are Revealing The Super Common Home Items From 20 Years Ago That You Can't Find "Anywhere" Today
Recently, we asked the BuzzFeed Community for examples of household items that were popular about 20 years ago, but you'd be hard-pressed to find them in homes now. The responses were a true throwback, and the nostalgia is real. Here are just 15 once ubiquitous home staples: Responses have been edited for length and clarity. 1."A home computer. My boyfriend, my father, and I all have our own PCs now. I remember I used to watch YouTube videos on my dad's lap on the Dell PC that ran Windows XP.
"They Are Hard To Maintain And Expensive To Install": 15 Super Common Household Items From 20 Years Ago Or Earlier That've Totally "Disappeared"
Recently, we asked the BuzzFeed Community for examples of household items that were popular about 20 years ago, but you'd be hard-pressed to find them in homes now. The responses were a true throwback, and the nostalgia is real. Here are just 15 once ubiquitous home staples: Responses have been edited for length and clarity. 1."A home computer. My boyfriend, my father, and I all have our own PCs now. I remember I used to watch YouTube videos on my dad's lap on the Dell PC that ran Windows XP.
15 Very Specific Items Non-Americans Assume Every Single American Automatically Has In Their Home
Recently, we asked non-Americans in the BuzzFeed Community about household items they're certain every American household has. The responses were funny, wide-ranging, and (well) relatable. Here are just 15 standout items you might expect to find in a house here in the US: Responses have been edited for length and clarity. 1."Garbage disposals under sinks feel like a uniquely American thing.
Tell Us The "Problematic" Things That Were Once So "Normal" But Could NEVER Happen Now
It's a tale as old as time to look back and realize some things that once felt so standard while living through them years ago now look so very antiquated. Take, for example, smoking on planes. It wasn't banned until 2000 when then-president Bill Clinton signed an act prohibiting smoking on all US flights. Michael Ochs Archives / Getty Images Similarly, did you know it wasn't until 1984 that New York required people to wear seat belts when driving? They were the first state to issue such a mandate.
Tell Us The "Problematic" Things That Were Once So "Normal" But Could NEVER Happen Now
It's a tale as old as time to look back and realize some things that once felt so standard while living through them years ago now look so very antiquated. Take, for example, smoking on planes. It wasn't banned until 2000 when then-president Bill Clinton signed an act prohibiting smoking on all US flights. Similarly, did you know it wasn't until 1984 that New York required people to wear seat belts when driving? They were the first state to issue such a mandate.
Last year we signed the Secure by Design pledge - here's our progress
Blog Security Last year we signed the Secure by Design pledge - here's our progress Learn about GitLab's CISA-aligned additions and improvements around MFA, default password reduction, patching, and vulnerability disclosure. DevSecOpsDevSecOps platformsecuritypublic sector A little over a year go, GitLab signed CISA’s Secure by Design Pledge, a directive for technology providers to embed security at the heart of their products from the outset of development.
15 “Ew...That Gave Me The Ick" Relationship Red Flags That Are Secretly Huge Green Flags
Red flag this, green flag that. When dating, people have so many characteristics they look for in a partner. Or more truthfully, traits they try to avoid. Sometimes, though, one person's red flag is another person's green flag. We asked the BuzzFeed Community for examples of things that, when dating, some might see as a reason for pause, but they see as a good thing. The responses were fascinating: Responses have been edited for length and clarity. 1."Not having social media.
"I'm Falling In Love": Al Pacino Just Did Our Puppy Interview, And The Dogs Absolutely Adored Him
Al Pacino loves puppies, and the puppies looooove him! BuzzFeed In support of his highly anticipated new exorcism thriller The Ritual, the Oscar-winning actor stopped by to complete our Puppy Interview. XYZ Films / courtesy Everett Collection And let's just get it out of the way from the jump: It was a true delight. Hannah So / BuzzFeed The legendary actor was game to discuss everything, like why he turned down Star Wars, which was the "biggest offer" he'd ever had.
Tell Us What Item Every American House Had 20 Years Ago That's Totally Disappeared
Times change, and so do the things we use. It's hard to think of it now, but there was a time it seemed like every house had a VCR player. Related: Listen, It's Weird, But I Know Your EXACT Birth Month Based On Your Taste In Vegetables That's not the case anymore. So it begs the question: What's a household item that you used to find in every home but would be hard-pressed to come across today? It could be a stack of CDs... Related: How Long Would You Last In A Zombie Apocalypse?
Non-Americans, Tell Us What Specific Thing You Think Every American Has In Their Home
The world is more connected than ever, but that doesn't mean we all live the same way. A while back, we shared a Reddit thread highlighting different things non-Americans assumed every American has in their home. ANDREY DENISYUK / Getty Images You know, things like individual soda cans... Niuniu / Getty Images Related: Listen, It's Weird, But I Know Your EXACT Birth Month Based On Your Taste In Vegetables ...and a bunch of BBQ sauce.
Tell Us The Biggest Relationship "Red Flags" That Are Actually Huge "Green Flags"
Last month, we shared a Reddit thread highlighting major dating "red flags" that aren't actually a bad thing at all. Things like having a small group of friends. Or, being a "slow" responder over text. Related: Your Favorite Romantic Movies Will Reveal Your Love Language And, being friendly with your exes. Related: It's Freaky, I Know, But We Can Guess Your Birth Month Based On Your Cupcake Preferences Well, the responses to the post were overwhelming.
"Who Does That?!": 17 Totally Untrue "Lies" Movies And TV Shows "Tricked" Us Into Believing
Recently on Reddit, @Individual-Crazy3752 asked, "What's something you keep seeing in movies that no one actually does in real life and annoys you every time?" The responses were hilarious and so true, so here are just 17 that really stood out: 1."In older movies, when they light a cigarette, they toss it after one drag.
"I Was Bullied Horrifically For It": Older Adults Are Sharing Specific Things Today That Are 100% Better Than The Past
It's common for older people to wax nostalgic about the good ol' days. However, redditor @EnvironmentalZone189 recently asked, "What’s one part of modern life you actually prefer over how it used to be?" The responses were thoughtful, illuminating, and a true reminder that everyday aspects of life are constantly evolving. Here are 17 responses that really stood out: Responses have been edited for length and clarity.
15 Things People Today Can't Live Without That Older Adults Could Never Predict Would Be Invented
Recently on Reddit, @Late-Confidence339 asked, "What are some things that exist today that you couldn't even imagine back in your day?" Older people flooded the post with thoughtful and very informative answers. Here are just 15 responses about things that it's hard to imagine weren't always a part of everyday life: Responses have been edited for length and clarity.
People Are Revealing The Shocking "Secrets" They're Keeping From Their Partners And Will Never Admit
A while ago, Redditor @EvilSugarDealer asked, "What's a secret that you're never going to tell your partner?" This inspired us to ask the BuzzFeed Community to reveal major relationship secrets of their own. So here are just 21 "revelations" that stood out from Redditors and BuzzFeeders alike: The responses have been edited for length and clarity. 1."My boyfriend is Spanish, and he refers to our sprinklers in the yard as 'sprinkles'. Whenever he loses something, he says he 'cannot found it'.
Restaurant Workers Are Revealing The WORST Couples They Ever Served, And It's So Juicy
Dates are hard, and so is witnessing a particularly bad one. We asked the BuzzFeed Community for times they saw a public date go so, so, SO very wrong. As always, they didn't hold back. So here are 15 of the most "eek!" bad date stories they shared: 1."An extremely beautiful couple sat down at a very popular restaurant chain where I was a waiter at in my teenage years. I was their waiter, and everything seemed to be going smoothly. The man had a Rolex on.
29 Reallllllllly Good "New" Movies Coming Out In The Next Three Months That You'll Actually Want To See
Summer is almost here! That means a ton of highly anticipated films are about to hit theaters and streamers. So, embrace your inner cinephile and check out these 29 films coming out in June, July, or August.
29 Reallllllllly Good "New" Movies Coming Out In The Next Three Months That You'll Actually Want To See
5 hours ago “Fear not! For I shall lead ye to riches beyond your wildest dreams!” Inside a tiny recording booth in downtown Los Angeles, John Peck waited for a verdict from the voice-over engineer: Did the line sound pirate-y enough? Try again, the engineer suggested, perhaps with more throaty emphasis on …
"Overcompensating" Stars Benito Skinner And Mary Beth Barone Kiss While Playing Celebrity Guess Who
Search query "Overcompensating" Stars Benito Skinner And Mary Beth Barone Kiss While Playing Celebrity Guess Who Mon, May 19, 2025 at 8:04 PM UTC Benito Skinner and Mary Beth Barone are riding for Celebrity Guess Who? Taylor Miller / BuzzFeed You might know the comics as longtime BFFs and co-hosts of the popular podcast Ride. Taylor Miller / BuzzFeed Recently, though, they took their partnership to the next level, costarring in the hit new Prime Video comedy Overcompensating.
Restaurant Workers, What Was The "Worst" First Date You Ever Saw?
Look, if you're working in the service industry, you're destined to experience some unexpectedly awkward moments between customers. Nicoletaionescu / Getty Images And there's arguably no greater circumstance in which these moments arise than a date gone wrong. Nicoletaionescu / Getty Images So, in the spirit of commiseration, we want to hear about the cringiest, most eek-inducing, or just straight-up worst experience you had serving a couple on a date.
We Want To Know What Services And Tasks People "Literally Always" Forget To Tip For
On the internet, tipping culture is one of the most constantly debated topics. JJ Gouin / Getty Images And with the rise in app-based services like food delivery, home decor setup, and beauty treatments at home, there are never-ending opinions about what to tip for and how much. ISMOLOEX / Getty Images Related: Eat At Some Popular Restaurant Chains For A Day And I'll Guess Your Hair Color So we want to hear directly from people with their boots on the ground.
What Services Or Tasks Do Customers "Never" Remember To Tip For But Seriously Should?
On the internet, tipping culture is one of the most constantly debated topics. JJ Gouin / Getty Images And with the rise in app-based services like food delivery, home decor setup, and beauty treatments at home, there are never-ending opinions about what to tip for and how much. ISMOLOEX / Getty Images Related: Eat At Some Popular Restaurant Chains For A Day And I'll Guess Your Hair Color So we want to hear directly from people with their boots on the ground.
Hairstylists Are Revealing Huge "Mistakes" Clients Make That Have Them Wanting To Pull Their Own Hair Out
Finding a good hairstylist or barber is a tale as old as time. But the truth is that half the battle of nailing down the perfect haircut has to do with you! A while ago, Redditor @Pan_Beesly asked, "What are some helpful and unhelpful things that clients do when they come in for a haircut?" The responses remain as timely as ever.
"That Would Confuse Kids Today": Adults Are Sharing The "Fun" Childhood Things That'd Totally Shock Gen Alpha
Recently, we shared responses from Redditor @clumsypandaaaa asking, "What's something people did for fun that would totally confuse younger generations today?" The BuzzFeed Community's reaction to the post was truly significant. Many offered their own stories about favorite childhood activities that aren't so popular today. So here are another 17 bygone kid activities: Responses have been edited for length and clarity 1."Every kid had a bicycle.
How Productivity Solutions Can Transform Business Applications
Joe Longo, Co-Founder of Velosio, has over 30 years of proven success delivering revenue growth and shareholder value. I recently had the privilege of moderating a roundtable discussion with industry leaders in the business applications space. The conversation primarily focused on how modern, cloud-based applications and productivity platforms are reshaping the traditional sales and delivery approach—helping drive efficiency, scalability and overall business agility.
"One Of My Favorite Carpet Looks Of The Past Five Years": People Are Obsessed With Joey King's Met Gala Suit
Every May, all sorts of stars descend upon the Metropolitan Museum of Art in New York City for the Met Gala. Neilson Barnard/MG25 / Getty Images for The Met Museum/Vogue And this year was no different. The theme was Superfine: Tailoring Black Style. Inspired by Monica L.
People Are Sharing The Super Common Things From 20 Years Ago That Have "Disappeared" Today
Recently, on Reddit, user @u/adityamishrxa asked, "What has gradually disappeared/discontinued in our surroundings over the last 20 years without anyone really noticing it?" The answers were fascinating and, in some cases, quite sad. Here are 15 that stood out: Responses have been edited for length and clarity. 1."Little toys in cereal boxes.
21 "Wait...That Was Them?!" Times Celebs Became Famous For Two Wildly Different Reasons
Recently on Reddit, user @TheLastSentenceIsGay asked, "Which person got attention for two completely unrelated things, making you think 'Wait, that was that guy!?'" The examples will simply blow your mind, so here are just 21 that stood out: Responses below have been edited for length, clarity, and accuracy.
19 “Wait, That’s Bad…Right?” Relationship Red Flags That Are Secretly The Biggest Green Flags
Recently, a Reddit user asked, "What is a red flag you hear people mention that you don’t think is [one]?" The responses were very honest and just straight-up so accurate, so here are 19 examples that really stood out: Responses have been edited for length and clarity. 1."Having a small group of new friends. The No. 1 red flag I've been told I've had is not having a single lifelong friend. All my friends are relatively new (5–10 years), and it's a small group.
"Young People Today Would Find This Deeply Problematic": 19 Things Kids Used To Do That You'd Never Do Now
Recently, redditor @clumsypandaaaa asked, "What's something people did for fun that would totally confuse younger generations today?" The responses are a fascinating look at how technology, health and safety rules, and culture have altered how kids spend their free time. Here are 19 responses that stood out: Responses have been edited for length and clarity. 1."My friend's dad used to take them to the airport to give their mother a break once a month.
Men Are Revealing The Jaw-Dropping Secrets They're Hiding From Their Partners
A while ago, Redditor @EvilSugarDealer asked, "What's a secret that you're never going to tell your partner?" Surprisingly, the answers weren't all that grim. Many were unexpectedly wholesome or simply just a little funny. Here are 17 that stood out: Responses have been edited for length and clarity. 1."That I've got another bank account that I regularly deposit money into.
Non-Americans Are Revealing "Weird" Things About The US That Americans Don't Know Are Strange
A bit ago, redditor @rickyjones75 asked, "Non-Americans who have been to the US: What is the weirdest thing about America that Americans don't realize is weird?" The responses were passionate and very specific. Here are just 21 examples that stood out: Responses have been edited for length and clarity. 1."Coffee all the time. I got a tattoo in Barcelona and was completely embarrassed when I asked the artist if he wanted a coffee from next door.
17 Singers Who Tragically Died At The Height Of Their Careers, And It's Truly Heartbreaking
Paul Natkin / Getty Images Marvin Gaye rose to prominence in the '60s and had continued success through the '80s thanks to a string of hits like "How Sweet It Is (To Be Loved by You)," "I Heard It Through the Grapevine," "What's Going On," and "Sexual Healing." He died in 1984 at age 44 after being shot to death by his father the day before his 45th birthday, according to the New York Times.
"It's Very Cheap At $1.99 A Jar": 15 Shockingly "Normal" Things Canadians Literally Come To The US To Buy
Across Reddit, Canadians have been sharing for a while now the everyday essential items they'll come down to the US just to buy. These things are so everyday that it's pretty likely you already have several sitting on a shelf right now. Here are just 13 that stood out: These responses, which have been edited for length and clarity, were compiled from several Reddit threads: here, here, here, here, here, here, and here.
Show More
loading
Actions
Get in touch with Joseph
Contact Joseph, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack