Josh Bartz

Abstract Adult mammalian hearts exhibit minimal regenerative capacity, limiting most cardiac repair. In contrast, neonatal mice retain the ability to regenerate cardiac tissue for a brief period after birth. Although single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has deepened our understanding of this regenerative window, existing datasets remain dispersed across studies, hindering integrative and comparative analyses.

Abstract Biological aging is associated with progressively more severe genetic and epigenetic alterations. While these changes are expected to affect the transcriptional profile of cells, the magnitude of that effect is unknown as the aging transcriptome is still poorly understood. Understanding the aging transcriptional landscape will give us greater insight into how cells are affected by and/or respond to the aging process.

Abstract : Increasing stochasticity is a key feature in the aging process. At the molecular level, in addition to genome instability, a well-recognized hallmark of aging, cell-to-cell variation in gene expression was first identified in mouse hearts.