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Josh John Sekela on Muck Rack

Josh John Sekela

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Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility

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By Valentina Lagomarsino, Ariel Robinson, Perry Mitchell, Mira Jiang, Lauren Hutchinson, Patrick Caron, Kathleen I. Navas, Nur Hasan, Chantal Guillemette, Matthew R. Redinbo, Meenakshi Rao, Josh John Sekela, McKenzie K. Gehris, Murillo Duarte-Silva, Michael Netherland Jr.
| Nature Verified
Abstract The coordinated transit of intestinal contents is crucial for digestion and host defense, and is regulated by cross-talk between neural circuits, the muscular gut wall and luminal factors. Here we show that androgen signaling to Nos1+ enteric neurons and Scn10a+ spinal afferent neurons is required for normal intestinal transit in mice and is microbiome dependent.
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