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Joshua Biggs O'May on Muck Rack

Joshua Biggs O'May

As seen in: BioRxiv
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WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

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By Joshua Biggs O'May, Lesley Vanes, Leonard de Boer, Harald Hartweger
| BioRxiv
Abstract Signaling from the T cell antigen receptor (TCR) on CD4+ T cells plays a critical role in adaptive immune responses by inducing T cell activation, proliferation, and differentiation. We demonstrate that WNK1, a kinase implicated in osmoregulation in the kidney, is required in T cells to support T-dependent antibody responses.
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