Joshua Combs

Benzoxaborole inhibitors target an array of proteins through diverse modes of interaction. As a neutral species they can interact with the hinge motif of kinases, (1) and as the anionic boronate they can coordinate Lewis acidic metal atoms, (2,3) covalently bind to serine and threonine residues, (4) and perhaps most uniquely coordinate with the 2′,3′ cis-diol ribose sugar at the 3′ end of RNA (5,6) (Figure 1a).