Jouko Levijoki

PK pharmacokinetic RM repeated measures 1 INTRODUCTION Emesis is a physiological protective mechanism that helps to remove ingested noxious or harmful material from the gastrointestinal tract.1 In dogs, induced emesis is often the first step of decontamination after the ingestion of potentially toxic substances or foreign objects.2-6 The systemic absorption of toxic substances can be markedly reduced with timely use of appropriate emetics.7-9 Traditionally, dog owners have used oral hydrogen...

Abstract Cancer treatments are frequently associated with nausea and vomiting despite greatly improved preventive medication. Administration of antinausea agents as eye drops might provide easy and rapid access to the systemic circulation for prevention of nausea and vomiting and for the treatment of breakthrough nausea, but the ocular administration route has rarely been evaluated.

Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is increasingly common but there is currently no established pharmacological therapy. We hypothesized that ORM‐11035, a novel specific Na+/Ca2+ exchanger (NCX) inhibitor, improves cardiac function and remodelling independent of effects on arterial blood pressure in a model of cardiorenal HFpEF. Methods and results Rats were subjected to subtotal nephrectomy (NXT) or sham operation.