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Judy Button on Muck Rack

Judy Button

As seen in: Multiple Sclerosis and Related Disorders
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Articles

A Pharmacokinetic and Biomarker Study of Delayed-Release Dimethyl Fumarate in Subjects with Secondary Progressive Multiple Sclerosis: Evaluation of Cerebrospinal Fluid Penetration and the Effects on Exploratory Biomarkers

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By Keith Edwards, Judy Button, Vineetha Kamath, Aneesh Kamath
| Multiple Sclerosis and Related Disorders Verified
Highlights • Tmax of CSF MMF peak is 2 hours after plasma showing MMF crossing the blood brain barrier with potential direct penetration into the brain. • NfL CSF levels and GFAP show correlation with disease activity in SPMS • CSF NfL increase is significantly elevated and precedes clinical symptoms by many weeks • CSF NfL returns to baseline consistent with clinical improvement Abstract Background Biomarkers are a useful and reliable measure of disease activity in many fields of medicine.
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Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis

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By Keith Edwards, Judy O'Connor, Judy Button, Vineetha Kamath
| Multiple Sclerosis and Related Disorders Verified
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 NfL levels of CSF at baseline, 6-weeks, 28-weeks in the 16 patients with case report showing spike of NfL at 6-weeks.
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