Jueqin Lu on Muck Rack

Jueqin Lu

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Articles

Milk-derived extracellular vesicles mitigate NF-κB pathway and NLRP3 inflammasome formation in Long Evans neonates.

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By Jueqin Lu, Jasmyne A Storm, Mon Francis Obtial, Sanoji Wijenayake
| biorxiv.org
Abstract Exposure to a maternal high fat diet (HFD) during perinatal (prenatal and postnatal combined) life increases offspring's risk of developing metabolic diseases (obesity, type II diabetes and hypertension), impairs immunity, behavior, and neurodevelopment. Exclusive breast/chest milk feeding is a potential solution to reduce the negative developmental effects of HFD, mainly chronic systemic pro-inflammation.
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Human milk-derived extracellular vesicle treatment promotes the heat shock response in neonates with perinatal high fat diet exposure.

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By Jasmyne A Storm, Jueqin Lu, Mon Francis Obtial, Sanoji Wijenayake
| biorxiv.org
Abstract Maternal consumption of a high-fat diet (mHFD) during perinatal life (the collective prenatal and postnatal periods) influences neonatal development, initiates hypothalamic-pituitary-adrenal (HPA) axis activation, and impacts the long-term physiological and metabolic health of offspring.
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Human milk-derived extracellular vesicles promote the heat shock response in polarized microglia.

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By Jasmyne A Storm, Jueqin Lu, Sanoji Wijenayake, Mon Francis Obtial
| biorxiv.org
Abstract Proteotoxic stress induces microglia polarization and attenuates cytoprotective, pro-survival cellular cascades. Milk-derived extracellular vesicles (MEVs) are lipid-coated nanovesicles that combat pro-inflammation in peripheral cells and tissues; however, the cytoprotective potential of MEVs remains unknown in brain macrophages. We investigated whether MEVs reduce neuroinflammation in human microglia by activating the heat shock response (HSR).
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