Jueun Roh

1. Introduction Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage []. Nociceptive pain is mediated by nociceptors in response to specific stimuli, alerting the body to potential harm, avoiding harmful stimuli, and protecting the body []. Inflammation triggers inflammatory pain and contributes to certain neuropathic pain conditions.

Abstract : Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptive neurons innervate the intracranial meninges and convey pain signals from the meninges to the thalamus.