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Juhyeong Seo

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Articles

Honokiol induces an autophagy and apoptosis imbalance by modulating the p62 and Nrf2 signaling loop in canine osteosarcoma

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By Jiyeon Ham, Juhyeong Seo, Minha Jeong
| Nature Verified
Abstract Canine osteosarcoma is one of the most common cancers in dogs, primarily affecting large breeds, and is characterized by high metastatic potential and recurrence rates. However, effective treatments remain limited, necessitating the development of novel therapeutic agents. Therefore, we investigated the effects of honokiol, a bioactive compound extracted from the bark of Magnolia species, with a focus on apoptosis and autophagy, using the canine osteosarcoma cell lines DSN and D-17.
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