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Juji Ito

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Articles

Genetic study identifies novel genes in developmental dysplasia of the hip

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By Soichiro Yoshino, Shibo Chen, Ryosuke Yamaguchi, Konstantinos Hatzikotoulas, Yoshinao Koike, Daisuke Inoue, Kan Sasaki, Hyonmin Choe, Toshihiko Hara, Yaichiro Okuzu, Tomoyuki Nakamura, Gaku Koyano, Tomohiro Shimizu, Koichi Kinoshita, Eiji Takahashi, Takeshi Utsunomiya, Daisuke Hara, Taishi Sato, Shinya Kawahara, Ayumi Kaneuji, Takuaki Yamamoto, Daisuke Takahashi, Tetsuya Jinno, Koji Goto, Michiaki Takagi, Yutaka Inaba, Tamon Kabata, Satoshi Hamai, Goro Motomura, Lorraine Southam, J. Mark Wilkinson, Eleftheria Zeggini, Shiro Ikegawa, Yasuharu Nakashima, Chikashi Terao, Taishi Kurakazu, Yusuke Kohno, Juji Ito, Kyohei Shiomoto, Tsutomu Kawano, Taro Mawatari, Tetsuro Nakamura
| Nature Verified
Abstract Developmental dysplasia of the hip (DDH), a morphological abnormality of the hip joint, is a well-recognized risk factor for hip osteoarthritis (OA). Much remains unknown about the genetic factors of DDH and its subtypes. To further understand its genetic basis, we conducted genome-wide association studies (GWASs) using a total of 1 085 Japanese DDH cases (including 788 hip dysplasia cases without dislocation and 297 cases with dislocated hip) and 24 000 controls.
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