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Julia Beth Buczynski on Muck Rack

Julia Beth Buczynski

As seen in: Royal Society of Chemistry
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Synthesis of substituted norcaranes for use as probes of enzyme mechanism

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By Peter D. Giang, Luke Richard Churchman, Julia Beth Buczynski, Jeanette E Stok
| Royal Society of Chemistry Verified
Synthesis of substituted norcaranes for use as probes of enzyme mechanism Norcarane is a mechanistic probe of monooxygenase enzymes which is able to detect the presence of cationic or radical intermediates. The addition of substituents around the bicycloheptane ring of the norcarane scaffold can assist in improving enzyme binding affinity and thus improve the regioselectivity of oxidation.
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