Julia Conrad

Abstract The ternary complex, composed of eIF2, GTP and initiator methionyl-tRNA, delivers the first amino acid to the ribosome to initiate protein synthesis. Eukaryotic initiation factor 2B (eIF2B) catalyzes GDP to GTP exchange on eIF2, thereby setting the ternary complex level. Stress-induced phosphorylation converts eIF2 from the substrate of eIF2B into an inhibitor (eIF2-P). This conversion reduces ternary complex levels and induces the integrated stress response (ISR).

Bach’s music has been recorded on synthesizer, launched into outer space, and inspired 300 years of Western classical music. Now, it’s on OnlyFans. On May 13, the Berlin-based violist, composer, and arranger Shasta Ellenbogen premiered the first of a new series of solo viola performances on OnlyFans.

“Madam, you have between your legs an instrument capable of giving pleasure to thousands, and all you can do is scratch it,” the English conductor Sir Thomas Beecham is said to have told a cellist during a rehearsal. The quip is still played for laughs, dredged up by the likes of Classic FM (“The best conductor insults”) and, apparently, Sir Georg Solti, who repeated it during a Chicago Symphony Orchestra rehearsal in 1995.