Julia Elizabeth Rood on Muck Rack

Julia Elizabeth Rood

As seen in: The Journal of Immunology
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Articles

Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses

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By Julia Elizabeth Rood, Suh Yoon, Mary Heard, Stephen D Carro
| biorxiv.org
Abstract Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines elicit robust CD4+ T cell responses, which are essential for antiviral immunity.
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Murine hemophagocytic lymphohistiocytosis can occur in the absence of interferon-gamma.

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By Thomas Niels Burn, Julia Elizabeth Rood, Lehn Weaver, Portia A Kreiger, Edward M Behrens
| The Journal of Immunology Verified
Hemophagocytic lymphohistiocytosis (HLH) is an ultimately fatal disease manifesting as a result of a dysregulated systemic hyperinflammatory response. Infection of perforin knockout (PKO) mice with an acute strain of lymphocytic choriomeningitis virus (LCMV) mimics the human disease. Based on this murine model, the current dogma suggests that disease is driven by excessive production of interferon gamma (IFNγ) by hyper-proliferative, LCMV specific CD8+ T cells.
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