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Julia F. Baroth on Muck Rack

Julia F. Baroth

As seen in: Nature
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Single-molecule studies reveal that p53 non-specifically samples nucleosomes to form short-lived complexes with its response element

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By Lisa Brady, James Goodrich, Jennifer F. Kugel, Julia F. Baroth, Tyler J. Koo
| Nature Verified
Abstract The transcription factor p53 is a tumor suppressor protein that regulates the expression of genes controlling cell fate decisions. Tetrameric p53 binds to DNA sequences known as response elements (RE) to control transcription via interactions with co-regulatory complexes. It is unclear, however, how p53 recognizes and binds to REs that are occluded when DNA is wrapped around histone octamers to form nucleosomes.
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