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Julia Hubbard on Muck Rack

Julia Hubbard

As seen in: BioRxiv
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Articles

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria

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By Hannah Gaimster, Daniel Stevens, Julia Hubbard, Katarzyna Mickiewicz
| BioRxiv
Abstract Cellular proliferation relies on successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilise regulatory pathways that ensure DNA replication initiation only occurs once per cell cycle. When dysregulated, loss of DNA replication control can have severe consequences. In Escherichia coli it has been observed that hyper-initiation of DNA synthesis leads to pleiotropic genome instability and cell death.
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