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Candida albicans colonizes different parts of the human body, such as the skin, gut, and genital and oral tracts, and does not normally cause disease in immunocompetent individuals [1]. However, in immunocompromised patients, C. albicans can cause both mucosal and invasive candidiasis [2].
The interaction between the Candida albicans cell wall and pattern recognition receptors is crucial for the initiation of host immune responses, which, ultimately, contribute to the clearance of this pathogenic fungus. In the present study, we investigate the ability of C. albicans mannans to modulate immune response and induce innate immune memory (also termed trained immunity). Using mutants of C.
Diabetes is a highly prevalent disease accompanied by chronically elevated plasma glucose levels. Hyperglycemia is the driver of microvascular complications associated with diabetes and has also been implied to be a risk factor for macrovascular complications like stroke (1). It has been well established that the presence of diabetes impacts the immune system (2).
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