Julia M. Bartlett
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Confessions of a Mango
Gr 3-7–Coventry narrates Lumsden and Pieplow’s coauthored middle grade novel, which focuses on themes of self-worth, academic troubles, and neurodevelopmental support. Ruby is a new student at Benton Academy, a highly competitive middle school. Making friends comes easily to her, but she has a hard time keeping up with the other students because of her dyslexia, dysgraphia, and dyscalculia. Her twin brother, Bryce, on the other hand, thrives in the academically demanding environment.
Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder
Abstract Affective biases shape cognitive and emotional behaviour and are important in major depressive disorder (MDD). Modulation of affective biases by the NMDA antagonist, ketamine, may underlie its antidepressant effects but not all NMDA antagonists are efficacious.
Modulation of negative affective biases in male rats may predict the rapid and sustained antidepressant effects of different NMDA antagonists
Abstract Affective biases influence cognitive and emotional behaviour and play a significant role in major depressive disorder. We have shown that the NMDA antagonist and rapid-acting antidepressant, ketamine, selectively modulates affective biases, a neuropsychological effect which may underlie its efficacy. Clinical studies with different NMDA antagonists have found mixed effects but the reasons for these differences in efficacy are not understood.
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