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Articles by Julia Schäffer
Persistent cognitive impairment and bone health following helium ion exposure: implications for space travel
Abstract This study investigated the long-term neurobehavioral and physiological impacts of low-dose helium (4He) ion exposure—a key component of galactic cosmic radiation—on male Long Evans rats. After training on the rodent psychomotor vigilance test (rPVT), the rats were irradiated and monitored for up to 180 days to assess sustained attention and social recognition memory, alongside blood and bone analyses.
Risk reshapes amygdala representation of choice
Keywords risk punishment choice nucleus accumbens calcium imaging optogenetics decision-making conflict sequencing anxiety Introduction The ability to modify actions when environmental conditions change is a hallmark of adaptive behavior, such as when animals adjust their responding for a desired outcome upon its association with the risk of an aversive consequence or punishment.1,2 In humans, tolerance for risk varies across individuals and is aberrant in various neuropsychiatric...
Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation
Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation
Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adi-Pose Tissue of Mice
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IJMS | Free Full-Text | n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout
4. Materials and Methods 4.1. Animals The animal experiments were approved by local authorities (Regierungspräsideum Giessen: GI 20/10 Nr. G46/2017) and were performed in accordance with international legislation and the German Animal Welfare Act. All mice were obtained through in-house breeding in groups and kept under specific pathogen-free conditions on a 12 h day/night cycle at 22 ± 1 °C, relative humidity at ~50% with free access to standard laboratory chow and water.
Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations
Introduction Chronic exposure to cigarette smoke (CS) is a major trigger of chronic obstructive pulmonary disease (COPD), which affects more than 174 million people worldwide [1]. COPD comprises pulmonary inflammation, airway obstruction, pulmonary emphysema and often pulmonary hypertension (PH) [2].
Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations
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Ramping activity in midbrain dopamine neurons signifies the use of a cognitive map
Abstract Journeys to novel and familiar destinations employ different navigational strategies. The first drive to a new restaurant relies on map-based planning, but after repeated trips the drive is automatic and guided by local environmental cues1,2. Ventral striatal dopamine rises during navigation toward goals and reflects the spatial proximity and value of goals3, but the impact of experience, the neural mechanisms, and the functional significance of dopamine ramps are unknown4,5.
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