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Julia Wirmer-Bartoschek on Muck Rack

Julia Wirmer-Bartoschek

As seen in: Wiley Online Library, ACS Publications
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Articles

Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter

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By Ines Burkhart, Vivien McKenney, Julia Wirmer-Bartoschek, J. Tassilo Grün
| dx.doi.org
ACS Chemical Biology Cite this: ACS Chem. Biol. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.
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Exploring the Modulation of the Complex Folding Landscape of Human Telomeric DNA by a Low Molecular Weight Ligand

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By Ines Burkhart, Julia Wirmer-Bartoschek, Janez Plavec, Harald Schwalbe
| Wiley Online Library Verified
1 Introduction DNA G-quadruplexes (G4s) are noncanonical DNA structures formed in guanine-rich sequences, consisting of stacked guanine tetrads stabilized by Hoogsteen hydrogen bonds and the monovalent cations K+ or Na+.[1, 2] G4s are distributed across key genomic regions,[3] including telomeres,[4, 5] oncogene promoters,[6-9] and replication origins where their transient formation is involved in transcriptional regulation,[10, 11] genome stability,[12] and replication.[13] Consequently, G4s...
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Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding

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By J. Tassilo Grün, Anja Blümler, Ines Burkhart, Julia Wirmer-Bartoschek
| ACS Publications
Introduction More than 40% of human gene-promoter regions, in particular oncogenes, contain guanosine-rich DNA sequences that can form multiple different, coexisting G-quadruplex (G4) structures.(1−4) This structural polymorphism(5−8) is inherent to G4-forming sequences, but only recently, additional aspects of novel, noncanonical folding isomerism have been discovered: G4s with more than four G-rich tracts (“spare-tires”) close in sequence can isomerize by involving different G-tracts into...
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