Julia Wortman

1 INTRODUCTION Over the past years, clinicians may have encountered scientific publications describing potential pharmacokinetic (PK) drug–drug interactions involving the four isoxazolyl penicillins cloxacillin, dicloxacillin, flucloxacillin and oxacillin. Most of these articles show a trend of decreased exposure and efficacy of several drugs during concomitant treatment with an isoxazolyl penicillin.