Julia Y Mescheriakova

Abstract Objective In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic loci on the antiviral IgG titers. Methods IgG levels against EBNA-1 and varicella zoster virus (VZV) as control were measured.

Fatigue is reported by more than 75% of multiple sclerosis (MS) patients. In an earlier study, we showed that fatigue is not only a common symptom in patients at time of clinically isolated syndrome (CIS; fatigued 46%) but also predicts subsequent diagnosis of clinically definite multiple sclerosis (CDMS). The course of fatigue after CIS is unknown. We aimed to explore the long-term course of fatigue after CIS. In this study, 235 CIS patients, aged 18–50?years, were prospectively followed.