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Human melanomas frequently harbor amplifications of EZH2. However, the contribution of EZH2 to melanoma formation has remained elusive. Taking advantage of murine melanoma models, we show that EZH2 drives tumorigenesis from benign BrafV600E- or NrasQ61K-expressing melanocytes by silencing of genes relevant for the integrity of the primary cilium, a signaling organelle projecting from the surface of vertebrate cells.
Skin is a densely innervated organ10 with major nerve bundles (NB) visible in both intact skin and in skin healing from full-thickness excisional wounds (Fig. 1a). To determine the potential involvement of skin innervation in wound healing, we first used genetic lineage tracing to study the fate of nerve-derived cells upon skin wounding.
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