Julius Ryan D. Pronto on Muck Rack

Julius Ryan D. Pronto

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Articles

Targeting intracellular cholesterol imbalance rescues sarcomere–ER contact site signaling and ER remodeling in dilated cardiomyopathy

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By Nadezda Ignatyeva, Hafiza Nosheen Saleem, Wenjing Zhang, Sophie Schon, Zhengyi Yang, Anna M. Steyer, Henning Urlaub, Torsten B. Rasmussen, Jens Mogensen, Michael Radke, Halyna R. Shcherbata, Andreas Janshoff, Samuel Sossalla, Torben Ruhwedel, Karl Toischer, Britta Brügger, Volker Haucke, Michael Gotthardt, Niels Voigt, Antje Ebert, Cleophas Cheruiyot, Ruheen Wali, Daria Plota, Soeren Brandenburg, Julius Ryan D. Pronto, Yannic Döring, Wiebke Moebius
| Nature Verified
Abstract Dysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective lipid signaling destabilizes failing cardiomyocytes (CMs) at the molecular level remains elusive.
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