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Abstract Targeting the lateral habenula (LHb), a key brain region regulating alcohol consumption, presents a promising framework for reducing drinking. LHb neurons exhibit high sensitivity and responsiveness to the intravenous anesthetic propofol. However, whether and how propofol-activated habenular neurons regulate alcohol drinking remains unknown. Here, we show that a single dose of propofol rapidly and persistently reduces alcohol consumption in mice for approximately six days.
1 Introduction Lung cancer remains the most lethal malignancy globally, with non-small–cell lung cancer (NSCLC) accounting for approximately 85% of all cases [1, 2]. Despite recent breakthroughs in molecularly targeted therapies and immune checkpoint inhibitors, the clinical outcome of advanced or metastatic NSCLC remains unsatisfactory, primarily due to intrinsic and acquired resistance mechanisms [3-5].
Keywords neuropathic pain pain chronification nucleus accumbens chronic constrictive injury NAcS NAcC microcircuit Get full text access Log in, subscribe or purchase for full access. References 1. Hajihasani, A. ∙ Rouhani, M. ∙ Salavati, M. ... The Influence of Cognitive Behavioral Therapy on Pain, Quality of Life, and Depression in Patients Receiving Physical Therapy for Chronic Low Back Pain: A Systematic Review PM R. 2019; 11:167-176 2. Mansour, A.R. ∙ Baliki, M.N. ∙ Huang, L. ...
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