Jun Yong Oh

Abstract Senescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression. Eliminating senescent RPE cells has shown therapeutic potential, but conventional senolytics often lack the specificity required to spare non-senescent cells, raising safety concerns.

Review ACS applied materials & interfaces. 2025 May 9. doi: 10.1021/acsami.5c02810 Q18.32024 Jun Yong Oh  1  2, Kathleen E Villaseñor  1  3, Andrea C Kian  1  3, David P Cormode  1  3 作者单位 +展开 作者单位 1 Radiology Department, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States. 2 Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.