Jung-Soo Suh

In a recent study published in Cell, Liu et al.1 introduced EchoBack-CAR, a sonogenetic chimeric antigen receptor T cell platform that enables remote, spatiotemporal activation of CAR expression using focused ultrasound (FUS). By combining an evolved heat-inducible promoter with a synthetic positive feedback loop, EchoBack-CAR achieves potent antitumor effects while minimizing off-tumor toxicity.

1 Introduction Estrogen receptors (ERs), essential proteins located within the nucleus, play a pivotal role in the regulation of cell growth, differentiation, and survival. They function as the primary mediator of estrogen signaling across various tissues, especially within the female reproductive system.[1] ERs have two primary subunits, ER α and ER β, both of which are localized to the cytoplasm.

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