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Articles by Junjun Ding
Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability
Abstract Polysaccharides are known to be synthesized by enzymes in the endoplasmic reticulum and Golgi apparatus and transported through the secretory pathway to the cell surface or extracellular space, where they mediate essential biological processes. While classical localization and functions of polysaccharides are well established, their presence and potential roles in the nucleus remain unclear.
Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina - Communications Biology
Abstract In migratory fibroblasts, front-rear polarity is defined by the centrosome positioned anterior to a rearward nucleus. To achieve this polarity, actin cables couple to nuclear membrane proteins nesprin-2G and SUN2 and drive the nucleus backward. Aging disrupts this polarity by increasing SUN1, a SUN2 homolog.
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance - Nature Chemical Biology
Abstract RAF protein kinases are major RAS effectors that function by phosphorylating MEK. Although all three RAF isoforms share a conserved RAS binding domain and bind to GTP-loaded RAS, only ARAF uniquely enhances RAS activity. Here we uncovered the molecular basis of ARAF in regulating RAS activation. The disordered N-terminal sequence of ARAF drives self-assembly, forming ARAF–RAS condensates tethered to the plasma membrane.
Elevated SUN1 promotes aging-related polarity defects through mechanical coupling microtubules to the nuclear lamina
Abstract In migratory fibroblasts, the front-rear polarity required for cell migration is defined by an anterior centrosome relative to the nucleus. To achieve this polarity, actin cables drive the nucleus backward by coupling to nuclear membrane proteins nesprin-2G and SUN2. Aging disrupts this cell polarity by increasing the protein levels of SUN1, a SUN2 homolog.
Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A - Nature Communications
Abstract Studies of laminopathy-based progeria offer insights into aging-associated diseases and highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A (MAD) is a largely unexplored form of atypical progeria that lacks lamin A post-translational processing defects. Using iPSCs derived from a male MAD patient carrying homozygous LMNA p.R527C, premature aging phenotypes are recapitulated in multiple mesenchymal lineages, including mesenchymal stem cells (MSCs).
Multiscale 3D genome rewiring during PTF1A-mediated somatic cell reprogramming into neural stem cells - Communications Biology
Abstract The genome is intricately folded into chromatin compartments, topologically associating domains (TADs) and loops unique to each cell type. How this higher-order genome organization regulates cell fate transition remains elusive. Here we show how a single non-neural progenitor transcription factor, PTF1A, reorchestrates the 3D genome during fibroblast transdifferentiation into neural stem cells (NSCs).
Photo-Induced, Phenylhydrazine-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides
1. Introduction Reductive hydrodehalogenation, an important chemical transformation, finds extensive applications in environmental protection, medicinal chemistry, and organic synthesis. This process plays a critical role in modifying bioactive molecules with halogen groups during the late stages, enabling precise structural adjustment. Moreover, it assumes a vital role in converting hazardous and long-lasting halogenated organic pollutants into eco-friendly compounds [1,2,3,4,5,6,7,8,9].
Visible-Light-Induced, Base-Promoted Transition-Metal-Free Hydrogenation of Aryl Halides with n-Butanol
Visible-Light-Induced, Base-Promoted Transition-Metal-Free Hydrogenation of Aryl Halides with n-Butanol Yiwei Zhu, Zhimin Wu, Hongcai Sun and Junjun Ding Abstract We propose an eco-friendly protocol for C-X bond reduction using visible light, eliminating the need for transition metals and performed in air. The desired hydrogenation reaction proceeds through a radical mechanism.
Long-term warming in a Mediterranean-type grassland affects soil bacterial functional potential but not bacterial taxonomic composition
Abstract Climate warming is known to impact ecosystem composition and functioning. However, it remains largely unclear how soil microbial communities respond to long-term, moderate warming. In this study, we used Illumina sequencing and microarrays (GeoChip 5.0) to analyze taxonomic and functional gene compositions of the soil microbial community after 14 years of warming (at 0.8–1.0 °C for 10 years and then 1.5–2.0 °C for 4 years) in a Californian grassland.
Nanoconfinement and Salt Synergistically Suppress Crystallization in Polyethylene Oxide
Download Hi-Res ImageDownload to MS-PowerPointCite This:Macromolecules 2020, XXXX, XXX Zheng Zhang Zheng Zhang Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, United States Junjun Ding Benjamin M. Ocko Julien Lhermitte Julien Lhermitte National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, New York 11973, United States Joseph Strzalka Chang-Hwan Choi Frank T. Fisher Frank T.
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