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Articles by Junjun Ni
Nitric Oxide Conjugation Transforms NIR-II AIEgens Into Potent Hypoxia-Tolerant Type I Photosensitizers
Junjun Ni, Yan Feng, and Jianquan Zhang contributed equally to this work. , , , et al. “Nitric Oxide Conjugation Transforms NIR-II AIEgens Into Potent Hypoxia-Tolerant Type I Photosensitizers.” Advanced Materials (2026): e73860. https://doi.org/10.1002/adma.73860 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author.
The dynamic impairment of synaptic transmission in the PCx-IL engram circuit contributes to early olfactory memory decline in Alzheimer’s disease
Abstract Olfactory dysfunction has emerged as a promising target for the early diagnosis and treatment of Alzheimer’s disease (AD). However, the mechanisms underlying neural circuit disruption associated with olfactory dysfunction in AD remain poorly understood. We conducted single-cell RNA sequencing (RNA-seq) and ex vivo electrophysiological studies to determine the link between olfactory memory in AD and dynamic synaptic transmission disorders in PCx-IL engram cell circuits.
Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease
1 Introduction Alzheimer's disease (AD) is a neurodegenerative disease characterized by multiple pathological features that collectively contribute to progressive cognitive decline.
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders
I. Introduction Evidence for the role of the cysteine protease cathepsin B (CTSB) in neurologic diseases has been extensively investigated and supported by CTSB gene knockout (KO) studies in mouse models of brain disorders. These animal model studies address the role of CTSB upregulation, observed in human patients with neurologic diseases, by evaluating the behavioral, pathologic, and biomarker outcomes of CTSB gene KO in disease models.
A general analytical solution for axisymmetric electro‐osmotic consolidation of unsaturated soil with semi‐permeable boundary
REFERENCES 1. Pore pressures, consolidation, and electrokinetics. J Soil Mech Found Div. 1968; 94(4): 899-922. 2. Electroosmosis-enhanced preloading consolidation via vertical drains. Can Geotech J. 1998; 35(3): 491-499. 3, . The two-dimensional consolidation theory of electro-osmosis. Geotechnique. 2003; 53(8): 759-763. 4, , . Numerical model of electro-osmotic consolidation in clay. Géotechnique. 2012; 62(6): 537-541. 5, , , .
A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF‐κB/NF‐E2‐related factor 2 activation
1 INTRODUCTION Neuroinflammation is implied in the initiation and pathological process of dementia, such as Alzheimer's disease (AD) (Heneka et al., 2015; Tran et al., 2022), and microglia play critical roles in neuroinflammation (Salter & Stevens, 2017; Wu, Sun, et al., 2013; Wu, Zhu, et al., 2013). As highly plastic cells, microglia can be derived into neurotoxic or neuroprotective phenotypes when exposed to stimuli.
Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice
Highlights • Mice exhibit helping behavior to a conspecific experiencing harm • The helping behavior is dependent on self-experience and social contact • Anterior cingulate cortex neurons change dynamically during this behavior • An ACC-mediodorsal thalamus neural circuit modulates the prosocial behavior Summary Many species living in groups can perform prosocial behaviors via voluntarily helping others with or without benefits for themselves.
How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES Alzheimer's Association. (2020). Alzheimer's disease facts and figures. Alzheimer's & Dementia, 16, 391–460. https://doi.org/10.1002/alz.12068 , , , , , , , , , & (2015). Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature Neuroscience, 18(11), 1584–1593. https://doi.org/10.1038/nn.4132 , , , , , , , , & (2015).
Analytical solution for heat exchange in energy pile ground considering smear effects
DATA AVAILABILITY STATEMENT Some or all data, models, or codes that support the findings of this study are available from the corresponding author upon reasonable request.
Crop sensitivity to waterlogging mediated by soil temperature and growth stage
1 Introduction In theory, optimal plant water balance may be realized through harmony between root water absorption and leaf transpiration (Ibrahim et al., 2018). Adequate water supply is essential for healthy plant growth, but when the soil becomes saturated, potentially resulting in plant waterlogging stress (Singhal et al., 2022).
Cathepsins and SARS‐CoV‐2 infection: from pathogenic factors to potential therapeutic targets
REVIEW ARTICLE This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/bph.16187. Abstract Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.
Research on Landslide Hydrology and Hydrogeological Disaster Monitoring
Open AccessEditorial by Wei Shao 1,2,*, Wen Nie 3 and Junjun Ni 4 1 Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources, Nanjing University of Information Science and Technology, Nanjing 210044, China 2 School of Hydrology and Water Resources, Nanjing University of Information Science and Technology, Nanjing 210044, China 3 School of Resources and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China 4...
Novel mutations in GJB1 trigger intracellular aggregation and stress granule formation in X-linked Charcot-Marie-Tooth Disease
Introduction Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of disorders characterized by progressive distal muscle weakness and atrophy, usually with foot deformities and sensory loss, as well as decreased tendon reflexes (Szigeti and Lupski, 2009). CMT usually starts in the first or second decade of life, although it may also affect infants or individuals with advanced age.
Frontiers | A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders | Neuroscience
Impact Factor 4.677 | CiteScore 5.4 More on impact › TABLE OF CONTENTS Jessica Proulx, Satomi Stacy, In-Woo Park and Kathleen Borgmann* Department of Microbiology, Immunology and Genetics at University of North Texas Health Science Center, Fort Worth, TX, United States Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function.
Tooth Loss Suppresses Hippocampal Neurogenesis and Leads to Cognitive Dysfunction in Juvenile Sprague-Dawley Rats
Jiangqi Hu1, Xiaoyu Wang1, Wei Kong2 and Qingsong Jiang1* 1Beijing Stomatological Hospital, Capital Medical University, Beijing, China 2Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Sciences, Beijing Institute of Technology, Beijing, China Background: Both animal studies and prospective observational studies on patients with neurodegenerative disease have reported a positive link between oral diseases and cognitive function.
Frontiers | Anomalous Levels of CD47/Signal Regulatory Protein Alpha in the Hippocampus Lead to Excess Microglial Engulfment in Mouse Model of Perioperative Neurocognitive Disorders | Neuroscience
Introduction Perioperative neurocognitive disorders (PNDs) are common complications of surgical patients, especially in elderly patients. The PNDs are characterized by reduction in hippocampus-dependent cognitive functions involving impairment in memory, consciousness, and attention (Evered et al., 2018; Subramaniyan and Terrando, 2019).
Trans ε-Viniferin Decreases Amyloid Deposits With Greater Efficiency Than Resveratrol in an Alzheimer’s Mouse Model
Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the first cause of dementia in the world. Each year, there are over 9.9 million new cases of dementia worldwide, implying one new case every 3 s (Prince, 2015). Thus, in the world, nearly 50 million people have Alzheimer’s or related dementia as published by the Alzheimer’s association in 2021.
Author Correction: Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice | Scientific Reports
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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