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Articles by Junnan Chen
Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections
Abstract Host resistance to infection is initially determined by how well primed the innate immune system is to respond on first exposure to an invader, yet the mechanisms underlying this priming remain incompletely understood. Here we found that basal autophagy suppressed the expression of Il1a in alveolar macrophages (AMs) and an otherwise protective innate immune priming against Staphylococcus aureus and influenza A virus (IAV), independently of the microbiome and adaptive immunity.
An Accurate Land Cover Classification Map in China Integrating High-resolution Satellite Imagery and Planning Data with Deep Learning
Abstract This study presents a planning-oriented high-resolution land cover dataset for China, developed to address the limitations of existing products in territorial spatial planning and regional land analysis.
Large language models enhance annotation of enzymes in metagenomes
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Metagenomic data have notable biological potential, but their functional interpretation is frequently impeded by incomplete protein function annotations.
Oligonucleotide–siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease partly caused by gain-of-function mutations in superoxide dismutase 1 (SOD1). Here we developed RAG-17, an siRNA-targeting SOD1, using an accessory oligonucleotide conjugate platform for enhanced central nervous system (CNS) delivery.
Highly accurate prophage island detection with PIDE - Genome Biology
The phage and prokaryotic proteins from UniRef50 database (May 2024 version) were downloaded for training the classification model [40]. The phage dataset comprised 263,843 sequences, while the bacteria and archaea dataset contained 40,572,403 sequences. Highly similar sequences to those in the phage dataset were removed from the bacteria and archaea datasets with cd-hit-2d (sequence similarity > 95%) [41], resulting in 40,566,921 sequences.
Peptide-Functionalized Nanocapsules for Targeted Inhibition of β2-Microglobulin Amyloid Aggregation Dialysis-related amyloidosis (DRA) is a severe complication in patients undergoing long-term dialysis, primarily driven by the deposition of β2-microglobulin (β2m) amyloid fibrils. The effective sequestration and removal of β2m from the bloodstream represent key therapeutic strategies for managing DRA.
Controlling the Polarity of Metal-Organic Frameworks to Promote Electrochemical CO2 Reduction
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie202416367-sup-0001-misc_information.pdf2.6 MB Supporting Information References 1, , J. Am. Chem. Soc.
FEDKEA: Enzyme function prediction with a large pretrained protein language model and distance-weighted k-nearest neighbor
Abstract Recent advancements in sequencing technologies have led to the identification of a vast number of hypothetical proteins, surpassing current experimental capabilities for annotation. Enzymes, crucial for diverse biological functions, have garnered significant attention; however, accurately predicting enzyme EC numbers for proteins with unknown functions remains challenging.
Zn-ion doped BiOBr for enhanced photocatalytic degradation of methyl blue
Zn-ion doped BiOBr for enhanced photocatalytic degradation of methyl blue In this work, BiOBr photocatalysts dopped with zinc ions were manufactured to improve their photocatalytic degradation of methyl blue (MB). Among them, Zn2+/BiOBr-8 exhibited the highest photodegradation efficiency of MB after 100 min of illumination. After six-cycle experiments, it was found that its photocatalytic performance remained at a high level.
Selective Upcycling of Polyethylene over Ru/H‐ZSM‐5 Bifunctional Catalyst into High‐Quality Liquid Fuel at Mild Conditions
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
High-Speed Cell Assembly with Piezo-Driven Two-Finger Microhand
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Spatially and Temporally Resolved Dynamic Response of Co-Based Composite Interface during the Oxygen Evolution Reaction
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals
Back to Journals » International Journal of General Medicine » Volume 16 Original Research Oncology Authors Wu S, Chen J, Huang E , Zhang Y Received 14 August 2023 Accepted for publication 6 November 2023 Published 24 November 2023 Volume 2023:16 Pages 5527—5548 DOI https://doi.org/10.2147/IJGM.S434076 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Scott Fraser Shaoping Wu,1 Junnan Chen,1 Enmin Huang,2– 4 Yongfa...
Adsorption of Gold from Copper-Tartrate-ThiosulfateSolutions with Ion-Exchange Resins
Open AccessArticle by 1,2, 1,2, 1,2,*, 2 and 1,2 1 Key Laboratory for Ecological Metallurgy of Multimetallic Ores (Ministry of Education), Northeastern University, Shenyang 110819, China 2 School of Metallurgy, Northeastern University, Shenyang 110819, China * Author to whom correspondence should be addressed.
(001)-TiO2 nanosheets loaded on BiOI improve carrier separation and enhance the photocatalytic activity
(001)-TiO2 nanosheets loaded on BiOI improve carrier separation and enhance the photocatalytic activity Xin Mai, Ran Gao, Yeheng Zhang, Junnan Chen, Chengli Mai and Wensong Lin Abstract (001)-TiO2/BiOI photocatalysts with microsphere morphology were synthesized by a solvothermal method. The (001)-TiO2/BiOI was demonstrated with the highest photocatalytic performance for RhB degradation rate of 0.049 min-1 under visible light, which is 5 and 7 times of (001)-TiO2 and BiOI, respectively.
This tenure denial should make us question the tenure process as a whole
The following is a guest contribution and reflects the author’s views alone. For information on how to submit to the Opinion Section, click here. Many students may not be familiar with Professor Erin Y. Huang, but we consider her one of Princeton University’s finest instructors.
Highly Efficient Electro‐reforming of 5‐Hydroxymethylfurfural on Vertically Oriented Nickel Nanosheet/Carbon Hybrid Catalysts: Structure-Function Relationships - Lu - - Angewandte Chemie International Edition - Wiley Online Library
Research Article Xingyu Lu, Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, Liaoning, 110016 China School of Materials Science and Engineering, University of Science and Technology of China, Shenyang, Liaoning, 110016 China These authors contributed equally to this work.
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