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Yingjun Dong on Muck Rack

Yingjun Dong

As seen in: Wiley Online Library, arXiv, BioRxiv, Cell Press, Canadian Journal of Infectious Diseases & Medical Microbiology, Texas Medical Center
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Articles

Rational design of G i -biased CB1 agonist with reduced side effects

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By Jinxin Che, Linjie Li, Lin-Lin Wu, Huibing Zhang, Dan-Dan Shen, Yingjun Dong, ShaoKun Zang, Na Zhang, Hao Wang, Yan Zhang, Xiaowu Dong, Xiao-Ming Li, Yu-Ying Liao, Yu-Ying Liao, Yun-Tao Gao, Yun-Tao Gao, Jianheng Xue, Jianheng Xue, Jia-Xue Hu, Jia-Xue Hu, Meng-Ting Hu, Meng-Ting Hu, Linghua Xie, Linghua Xie
| Cell Press Verified
Keywords signaling bias CB1 cannabinoid rational design analgesic non-opioid Get full text access Log in, subscribe or purchase for full access. References 1. Thapa, D. ∙ Warne, L.N. ∙ Falasca, M. Pharmacohistory of Cannabis Use-A New Possibility in Future Drug Development for Gastrointestinal Diseases Int. J. Mol. Sci. 2023; 24, 14677 2. Graczyk, M. ∙ Łukowicz, M. ∙ Dzierzanowski, T. Prospects for the Use of Cannabinoids in Psychiatric Disorders Front. Psychiatry. 2021; 12, 620073 3.
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Generalizable Self-Supervised Learning for Brain CTA in Acute Stroke

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By Yingjun Dong
| Texas Medical Center
Computers in Biology and Medicine 10.1016/j.compbiomed.2024.109337 Author MSS Humans, Stroke, Supervised Machine Learning, Brain, Male, Computed Tomography Angiography, Female, Tomography, X-Ray Computed, Aged, Middle Aged yes Dong, Yingjun; Pachade, Samiksha; Roberts, Kirk; et al., "Generalizable Self-Supervised Learning for Brain CTA in Acute Stroke" (2025). Faculty, Staff and Student Publications. 734. https://digitalcommons.library.tmc.edu/uthshis_docs/734
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Structural Basis of GPCR-G Protein Pre-coupling and Activation: Insights from CCR1-Gi Complex

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By Zhehua Shao, Yingjun Dong, Ruixin Jia, Qingya Shen
| BioRxiv
Abstract GPCR-mediated G protein activation cycle contains obligated step of the receptor-G protein assembly before G protein activation (pre-coupling state). However, transient nature of this pre-coupling state has prevented structural and mechanistic understanding of this essential step of G protein activation cycle. In this study, we discover that CCR1 has high level of pre-coupling state, which allows its rapid response to chemokines.
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