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Abstract Rising antibiotic resistance has compromised the efficacy of standard Helicobacter pylori (H. pylori) eradication regimens. This multicenter trial aimed to evaluate whether a simplified tegoprazan-based triple therapy (TAD) is non-inferior to tegoprazan-based bismuth quadruple therapy (TADB) in a high-resistance setting.
Open AccessArticle by Junyan Du 1, Yiyu Xiao 1, Shiyuan Liu 1,*, Lijun Wang 1,* and Kuo-Chih Chou 2 1 Collaborative Innovation Center of Steel Technology, University of Science and Technology Beijing, Beijing 100083, China 2 State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, China * Authors to whom correspondence should be addressed.
We have developed a new methodology for label-free detection of alkaline phosphatase (ALP) activity based on a DNA hairpin and Thioflavin T (ThT) probes. In the presence of ALP, the 3’-phosphate of the primer DNA is dephosphorylated which triggered primer extension reaction to open the hairpin probe, and leading to releasing the G-quartets. These then bound to ThT to form ThT/G-quadruplexes with an obvious fluorescence generation.
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