Junying Gao

ABSTRACT Enteroviruses (EVs) are the major etiological agents of hand, foot, and mouth disease (HFMD), which could lead to severe complications and even fatalities. Owing to the alternating or co-circulation of multiple EV serotypes and the lack of cross-protection, global institutions are pursuing the development of multivalent HFMD vaccines.

Behavioral and histopathological analyses were conducted on 5×FAD mice within the GH group, SI group, GH-EE group, and SI-EE group to investigate the effects of physical EE and early SI on AD-like pathophysiology (Fig. 1A). The short-term spatial memory was assessed using the Y-maze test. The results indicated that, compared to GH-5×FAD mice, SI-5×FAD mice exhibited a significant decrease in both the time spent in the novel arm and the number of entries into the novel arm.

Resveratrol induces DNA damage-mediated cancer cell senescence through DLC1-DYRK1A-EGFR axis Fengqiu Ma, Yan Ma, Keke Liu, Junying Gao, Shasha Li, Xiaowen Sun and Guorong Li Abstract Inducing cell senescence is widely regarded as a potent tumor suppression mechanism. Resveratrol has attracted increasing attention for its capacity to prevent and suppress cancer. However, the mechanism of resveratrol on induction of cancer cell senescence has not been well clarified.