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Junyuan Yin on Muck Rack

Junyuan Yin

As seen in: Nature
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Articles

Physics-guided reinforcement learning for structured illumination microscopy

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By Junli Wu, Qiurong Yan, Siying Huang, Haoran Zhang, Junyuan Yin, Xiaolong Luo, Zhiqiang Wen
| Nature Verified
Abstract Structured illumination microscopy improves fluorescence imaging by shifting fine specimen information into the observable passband, but reconstructions often deteriorate when illumination phases, fringe contrast or noise depart from calibrated conditions. Existing learning-based methods usually compensate for these imperfections only after acquisition.
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USP5 regulates purine metabolism and represents a therapeutic target in esophageal cancer

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By Kexin Zhao, Lei Zhang, Mingyang Yan, Shaobo Fang, Zhenwei Wang, Yanming Song, Meng Liu, Chengjuan Zhang, Yang Shao, Manman Guo, Guoguo Jin, Zigang Dong, Xinyang Jia, Qinxin Guo, Junyuan Yin
| Nature Verified
Abstract Ubiquitination is a critical regulator of cancer development, yet the role of deubiquitinases in purine metabolism remains largely unexplored. In this study, untargeted metabolomic analysis revealed a significant upregulation of purine metabolism in esophageal cancer (ESCC). Database analysis further identified a strong positive correlation between the deubiquitinase USP5 and purine metabolism.
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