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Articles

Multilineage lymphoid clonal hematopoiesis: a cross-sectional, correlative analysis of plasma cell dyscrasias and large granular lymphocytic leukemia

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By Carlos Bravo-Pérez, Carmelo Gurnari, Arda Durmaz, Miguel Ruiz, Zachary Braunstein, Naomi Kawashima, Justin Jiang, Zachary Brady, Atsushi Marumo, Arooj Ahmed Verified, Mark D. Orland, Aashray Mandala, Luca Guarnera, Matteo D’Addona, Serhan Unlu, Christopher Haddad, Praveena S. Thiagarajan, Megan Nakashima, Heesun J. Rogers, Jonathan E. Brammer, Valeria Visconte, Jaroslaw Maciejewski, Kartik Lakhotiya
| Nature Verified
Abstract Clonal expansions in large granular lymphocytic leukemia (LGLL) may arise in response to immune dysregulation in the context of other hematologic malignancies. This study aimed to investigate the co-occurrence of LGLL and plasma cell dyscrasias (PCDs) to assess its prevalence, features, and potential underlying mechanisms. We conducted a cross-sectional study involving 2064 PCD cases and 534 LGLL cases.
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