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Justine Couble on Muck Rack

Justine Couble

As seen in: BioRxiv
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Articles

N6-methyladenosine primes the malaria parasite for transmission

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By Tiziano Vignolini, Justine Couble, patty chen, Selina Mussgnug
| BioRxiv
Abstract Sudden environmental changes are a recurring challenge for unicellular organisms, but a necessity for many to progress through their lifecycle. To transmit from its human host to mosquito vector, malaria parasites differentiate into male and female, semi-quiescent stages that can re-initiate development within seconds after transmission.
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A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite

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By Sebastian Baumgarten, Justine Couble, Tiziano Vignolini, Gregory A. Dore
| BioRxiv
Abstract The transmission of the most virulent human malaria parasite, Plasmodium falciparum, relies on its survival in the contrasting environments of the human host and mosquito vector. One of the most fascinating adaptations to this lifestyle is the specific silencing of individual rDNA genes in the human host that are de-repressed following host-to-vector transmission.
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Micro-C reveals MORC/ApiAP2-mediated links between distant, functionally related genes in the human malaria parasite

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By Parul Singh, Jacques Serizay, Justine Couble, Maureen D Cabahug
| BioRxiv
Abstract Genome organization plays a significant role in silencing heterochromatinized genes in the most virulent human malaria parasite, Plasmodium falciparum. However, it remains unclear how heterochromatinized genes spatially cluster or if active genes are also organized in a specific manner. We used Micro-C to achieve a near-nucleosome resolution DNA-DNA contact map, which revealed new inter- and intrachromosomal heterochromatic and euchromatic structures in the blood stage parasite.
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