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Abstract B cells regulate immune responses via antibody production and antigen (Ag) presentation. Although B cell depletion is used therapeutically, it may be associated with side effects, highlighting the need for alternative B cell–targeted approaches. While tolerogenic dendritic cells (tolDC) are known to modulate T cell responses, their impact on B cells is poorly defined. We show that IL-10–producing tolDC (DCIL-10) regulate B cell responses through direct and indirect mechanisms.
Author contributions: JS, FE, TK, SMvH and AtB designed the study. JS, AVB, LHK, MD and TJ performed experiments and analyzed data. MC, WO, GE, CM, AGAP, JJGV and MJvG provided essential technical support, samples and reagents. LW managed the participant database. LW, TWK and FE were involved in clinical recruitment. JS, AtB and SMvH wrote the manuscript. All authors critically reviewed the manuscript and gave final approval of the version to be published.
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