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The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): the immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-<50 and 50-<70 years old.
Keywords COVID-19 vaccination adaptive trial policy immunisation Panel: Research in context Evidence before this study We searched PubMed from inception until 29 May 2024, using the search terms “COVID*” AND “VACCIN*” AND “booster OR fourth dose” and restricted this search to randomised controlled trials (RCTs).
The Platform Trial In COVID-19 Priming and BOOsting (PICOBOO): the immunogenicity, reactogenicity, and safety of different COVID-19 vaccinations administered as a second booster (fourth dose) in AZD1222 primed individuals aged 50-<70 years old.
Keywords COVID-19 adaptive trial immunisation policy Panel: Research in context Evidence before this study We searched PubMed from inception until 24 April 2024, using the search terms “COVID*” AND “VACCIN*” AND “booster OR fourth dose” and restricted this search to randomised controlled trials (RCTs). We did not identify any RCTs evaluating second booster messenger ribonucleic acid (mRNA) and protein subunit vaccines in individuals primed with AZD1222.
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