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Ka Ying Chan on Muck Rack

Ka Ying Chan

As seen in: Nature
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Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism - Nature Communications

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By Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Lakhansing Pardeshi, Ye Ruan, Chi-Ming Wong, Yong-Juan Zhao, Ka Ying Chan, Xiyang Ma, Mary Chau, Franco King-Chi Leung, Kailei Sun, Chin Yu Mok, Fang Wang, Cong Ma, Yu-Hin Ho, Xiang-Yang Ye, Yajing zhang, Yan Zhao, Xiang Li, Gary M Tse, Xiao Shen
| Nature Verified
Abstract Tetrandrine (Tet) is a potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable photoaffinity probe, we identify lysosomal integral membrane protein-2 (LIMP-2) as a direct target of Tet and a key regulator of this calcium signaling. Tet binds LIMP-2’s ectodomain, inhibiting lysosomal cholesterol and sphingosine transport, which alters lipid metabolism.
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