Ka-Ying Wong

Introduction Aptamers are single-stranded oligonucleotides that selectively bind to target molecules.[1-4] With high binding affinity, excellent specificity, and ease of modification, aptamers have enabled innovative applications in biosensors, targeted drug delivery, chemical biology, and nanotechnology.[5-10] To implement these applications, it is critical to obtain high-quality aptamers, which are selected using a combinatorial biology method called systematic evolution of ligand by...

1 Introduction Nanozymes are nanomaterials that catalyze the conversion of enzyme substrates to products under physiologically relevant conditions, and some common substrates include glucose, hydrogen peroxide (H2O2), and 3,3′,5,5′-tetramethylbenzidine (TMB).[1-4] While the concept of nanozymes is often traced to early reports of peroxidase-like activity of Fe3O4 nanoparticles, and a Zn2+ complex immobilized on gold nanoparticles,[5, 6] studies from decades ago had already demonstrated the...

DELIVERING DRUGS to the eye remains a challenge due to the eye’s ability to rapidly eliminate foreign substances. To address this, various strategies have been developed to prolong drug residence time on the ocular surface, including the use of contact lenses (Pelusi et al, 2023). A promising approach involves integrating aptamers into contact lenses.