Kaamel Hafizi

1 INTRODUCTION Weight loss requires sustained negative energy balance, with pharmacotherapy being more effective than diet and exercise in promoting negative energy balance and ensuing weight loss (Khera et al., 2016). As weight loss progresses, humans display an increase in appetite (Doucet et al., 2000) and decrease in energy expenditure (EE) which is often precipitated downward at a greater rate than expected (Doucet et al., 2001).