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Kaely Tornek on Muck Rack

Kaely Tornek

As seen in: Nature
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Articles

ATR is a critical dependency gene for uveal melanoma

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By Michael Freeman, Geri Traver, Kaely Tornek
| Nature Verified
Abstract GNAQ, GNA11, CYSLTR2, and PLCB4 are well-characterized oncogenic drivers of uveal melanoma (UM). The oncogenic stress induced by these mutations creates a reliance on specific dependency genes that support tumor cell proliferation and survival. However, the genes that broadly contribute to UM cell fitness remain incompletely defined. Using the Dependency Map (DepMap), we identified ATR (HGNC:882; ATR checkpoint kinase) as a key regulator of UM cell fitness.
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