Kagenori Ito

Abstract Bladder cancer is classified by depth of invasion into muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC). Because some NMIBC cases progress to MIBC, it is important to elucidate the mechanisms of invasion. Spatial transcriptomics is a powerful tool for characterizing the tumor microenvironment.

1 Introduction Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease with a median survival of approximately 2 years from mCRPC diagnosis [1]. Among available treatment options, cabazitaxel 25 mg/m2 (C25) plus prednisone demonstrated efficacy over mitoxantrone in patients with mCRPC who were previously treated with docetaxel, based on results of the TROPIC trial [2]. Data also showed a high incidence of severe adverse events with cabazitaxel.

CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflicts of interest with the contents of this article. Supporting Information Filename Description gtc13105-sup-0001-Figures.docxWord 2007 document , 4 MB SUPPLEMENTARY FIGURE 1. Expression of major receptors of breast cancer in 18 cell lines. SUPPLEMENTARY FIGURE 2. Extraction of gene signatures associated with sensitivity to AR antagonists. gtc13105-sup-0002-Tables.docxWord 2007 document , 49.9 KB SUPPLEMENTARY TABLE 1.