Kahrisan Kunasingam on Muck Rack

Kahrisan Kunasingam

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A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy

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By Dominik Schaer, Nadja Schulthess-Lutz, Livio Baselgia, Kahrisan Kunasingam
| biorxiv.org
Abstract Tumor-associated macrophages (TAMs) can switch between immune-activating and cancer-promoting states; yet, the stress pathways that lock them into pro-cancerous states remain obscure. In MC38 colon tumors, repeated anti-CD40 or radiotherapy created necrosis that split TAMs into peripheral Cxcl9+ and peri-necrotic Spp1+ subsets.
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