Kai-An Cheng on Muck Rack

Kai-An Cheng

As seen in: Nature
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An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection

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By Chih-Wei Chen, Wei-Ting Liao, Yi-Han Chen, Shih-Che Weng, Shin-Hong Shiao, Zee-Fen Chang, Ching-Yang Kao, Yun-Jung Li, Kai-An Cheng
| Nature
Abstract Infections by RNA viruses cause diseases. Host factor(s) that restrain viral propagation offer new anti-virus strategies. We use vesicular stomatitis virus (VSV) as a model and observe the synthesis of VSV RNAs at mitochondria/endoplasmic reticulum (Mito/ER) spheres, accompanied by the leakage of endonuclease G (ENDOG), a mitochondrial nuclease, to the cytosol. We provide evidence that ENDOG released from mitochondria is a host anti-viral factor by eliminating viral RNAs for replication.
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