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Kai Sven Erdmann

As seen in: BioRxiv
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Articles

Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory

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By Weiwei Sun, Ahmed Salem, Kai Sven Erdmann, Pei Li Tseng
| BioRxiv
Abstract Cells sense and respond to mechanical cues from their environment. Mechanical cues are important for many biological processes, including embryonic development, ageing, cellular homeostasis, and diseases. Cells translate mechanical cues into cellular biochemical signals that govern cellular behaviour, like cell proliferation or migration, via a process called mechanotransduction. However, this process and the proteins involved remain incompletely understood.
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